Thermal behavior and stability of biodegradable spray-dried microparticles containing triamcinolone


Autoria(s): da Silva-Junior, Arnobio Antonio; de Matos, Jivaldo Rosario; Formariz, Thalita Pedroni; Rossanezi, Gustavo; Scarpa, Maria Virginia; Tabosa do Egito, Eryvaldo Socrates; Oliveira, Anselmo Gomes de
Contribuinte(s)

Universidade Estadual Paulista (UNESP)

Data(s)

20/05/2014

20/05/2014

23/02/2009

Resumo

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Thermal analysis has been widely used for obtaining information about drug-polymer interactions and for pre-formulation studies of pharmaceutical dosage forms. In this work, biodegradable microparticles of Poly (D,L-lactide-co-glycolide) (PLGA) containing triamcinolone (TR) in various drug:polymer ratios were produced by spray drying. The main purpose of this study was to study the effect of the spray-drying process not only on the drug-polymer interactions but also on the stability of microparticles using differential scanning calorimetry (DSC), thermogravimetry (TG) and derivative thermogravimetry (DTG), X-ray analysis (XRD), and infrared spectroscopy (IR). The evaluation of drug-polymer interactions and the pre-formulation studies were assessed using the DSC, TG and DTG, and IR. The quantitative analysis of drugs entrapped in PLGA microparticles was performed by the HPLC method. The results showed high levels of drug-loading efficiency for all used drug: polymer ratio, and the polymorph used for preparing the microparticles was the form B. The DSC and TG/DTG profiles for drug-loaded microparticles were very similar to those for the physical mixtures of the components. Therefore, a correlation between drug content and the structural and thermal properties of drug-loaded PLGA microparticles was established. These data indicate that the spray-drying technique does not affect the physico-chemical stability of the microparticle components. These results are in agreement with the IR analysis demonstrating that no significant chemical interaction occurs between TR and PLGA in both physical mixtures and microparticles. The results of the X-ray analysis are in agreement with the thermal analysis data showing that the amorphous form of TR prevails over a small fraction of crystalline phase of the drug also present in the TR-loaded microparticles. From the pre-formulation studies, we have found that the spray-drying methodology is an efficient process for obtaining TR-loaded PLGA microparticles. (C) 2008 Elsevier B.V. All rights reserved.

Formato

45-55

Identificador

http://dx.doi.org/10.1016/j.ijpharm.2008.09.054

International Journal of Pharmaceutics. Amsterdam: Elsevier B.V., v. 368, n. 1-2, p. 45-55, 2009.

0378-5173

http://hdl.handle.net/11449/7789

10.1016/j.ijpharm.2008.09.054

WOS:000263847400007

Idioma(s)

eng

Publicador

Elsevier B.V.

Relação

International Journal of Pharmaceutics

Direitos

closedAccess

Palavras-Chave #Triamcinolone #PLGA microparticles #Spray drying #Thermal analysis #X-ray analysis #Thermal stability
Tipo

info:eu-repo/semantics/article