Piroxicam encapsulated in liposomes: Characterization and in vivo evaluation of topical anti-inflammatory effect
Contribuinte(s) |
Universidade Estadual Paulista (UNESP) |
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Data(s) |
20/05/2014
20/05/2014
01/01/1999
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Resumo |
Liposomes of soya phosphatidylcholine, cholesterol, and stearylamine (molar ratio 6/3/1) and 0.1% alpha-tocopherol were prepared by the extrusion of multilamellar vesicles through 0.2-mu m polycarbonate membrane. Liposomes were characterized by electron transmission microscopy, and the mean structure diameter was 278 nm. The encapsulation efficiency obtained was 12.73%. The topical anti-inflammatory effect was evaluated in vivo by the cotton pellet granuloma method. We analyzed free piroxicam at 4 mg/kg, piroxicam encapsulated in liposomes added to 1.5% hydroxyethylcellulose (HEC) gel at 1.6 mg/kg, and piroxicam encapsulated in liposomes added to HEC gel at 4 mg/kg; the inhibition of inflammation obtained was 21.1%, 32.8%, and 47.4%, respectively. These results showed that the encapsulation of piroxicam produced an increase of topical anti-inflammatory effect, suggesting that the inhibition of inflammation can be obtained with lower drug concentrations. |
Formato |
1235-1239 |
Identificador |
http://dx.doi.org/10.1081/DDC-100102293 Drug Development and Industrial Pharmacy. New York: Marcel Dekker Inc., v. 25, n. 12, p. 1235-1239, 1999. 0363-9045 http://hdl.handle.net/11449/7694 10.1081/DDC-100102293 WOS:000084610500002 |
Idioma(s) |
eng |
Publicador |
Marcel Dekker Inc |
Relação |
Drug Development and Industrial Pharmacy |
Direitos |
closedAccess |
Tipo |
info:eu-repo/semantics/article |