Synthesis, characterization and antimycobacterial activity of Ag(I)-aspartame, Ag(I)-saccharin and Ag(I)-cyclamate complexes
Contribuinte(s) |
Universidade Estadual Paulista (UNESP) |
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Data(s) |
20/05/2014
20/05/2014
01/10/2007
|
Resumo |
The present work describes the synthesis and antimycobacterial activity of three Ag(I)-complexes with the sweeteners aspartame, saccharin, and cyclamate as ligands, with the aim of finding new candidate substances for fighting tuberculosis and other mycobacterial infections. The minimal inhibitory concentration of these three complexes was investigated in order to determine their in-vitro antimycobacterial activity against Mycobacterium tuberculosis, Mycobacterium avium, Mycobacterium intracellulare, Mycobacterium malmoense, and Mycobacterium kansasii. The MIC values were determined using the Microplate Alamar Blue Assay. The best MIC values found for the complexes were 9.75 mu M for Ag(l)-aspartame against M. kansasii and 15.7 mu M for Ag(I)-cyclamate against M. tuberculosis. |
Formato |
538-542 |
Identificador |
http://dx.doi.org/10.1002/ardp.200700040 Archiv Der Pharmazie. Weinheim: Wiley-v C H Verlag Gmbh, v. 340, n. 10, p. 538-542, 2007. 0365-6233 http://hdl.handle.net/11449/7633 10.1002/ardp.200700040 WOS:000250488600005 |
Idioma(s) |
eng |
Publicador |
Wiley-Blackwell |
Relação |
Archiv Der Pharmazie |
Direitos |
closedAccess |
Palavras-Chave | #antimycobacterial activity #MABA #silver-aspartame #silver-cyclamate #silver-saccharin |
Tipo |
info:eu-repo/semantics/article |