Potential tuberculostatic agents: Micelle-forming copolymer poly(ethylene glycol)-poly(aspartic acid) prodrug with isoniazid
| Contribuinte(s) |
Universidade Estadual Paulista (UNESP) |
|---|---|
| Data(s) |
20/05/2014
20/05/2014
01/06/2001
|
| Resumo |
With the objective of obtaining slow-acting isoniazid derivatives, of potential use as chemoprophylactics or chemotherapeutics in tuberculosis, the micelle-forming copolymer of poly(ethylene glycol)-poly(aspartic acid) prodrug with isoniazid was synthesized. The derivative obtained was found to be active in Mycobacterium Il(tuberculosis culture, with a minimal inhibitory concentration (MIC) 5.6 times lower than that of the tuberculostatic drug. |
| Formato |
189-193 |
| Identificador |
http://dx.doi.org/10.1002/1521-4184(200106)334:6<189 Archiv Der Pharmazie. Berlin: Wiley-v C H Verlag Gmbh, v. 334, n. 6, p. 189-193, 2001. 0365-6233 http://hdl.handle.net/11449/7577 10.1002/1521-4184(200106)334:6<189 WOS:000169717500002 |
| Idioma(s) |
deu |
| Publicador |
Wiley-Blackwell |
| Relação |
Archiv Der Pharmazie |
| Direitos |
closedAccess |
| Palavras-Chave | #potential tuberculostatic agent #isoniazid #prodrug #micelle-forming polymer #co-polymer poly(ethylene glycol)-poly(aspartic acid) |
| Tipo |
info:eu-repo/semantics/article |
