Mutagenic Activity of Indigofera truxillensis and I. suffruticosa Aerial Parts
| Contribuinte(s) |
Universidade Estadual Paulista (UNESP) |
|---|---|
| Data(s) |
20/05/2014
20/05/2014
01/01/2011
|
| Resumo |
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Indigofera truxillensis and I. suffruticosa, are used as a source of indigo dye and to treat several diseases. The mutagenic activity of the methanolic extracts from aerial parts, glycerolipid, flavonoid and alkaloid fractions of the extract were evaluated by means of Salmonella/microsome assays using TA100, TA98, TA102 and TA97a strains. The methanolic extract of I. truxillensis showed mutagenic activity in the TA98 strain without S9 while glycerolipid fraction was devoid of activity. The flavonoid and alkaloid fractions of both plants showed mutagenicity. Chemical analysis of flavonoid fractions of I. truxillensis and I. suffruticosa resulted in the identification of kaempferol, quercetin and their derivatives. The alkaloid fraction of both the species contained indigo and indirubin and indigo was found mainly responsible for the mutagenic activity. |
| Formato |
9 |
| Identificador |
http://dx.doi.org/10.1093/ecam/nep123 Evidence-based Complementary and Alternative Medicine. New York: Hindawi Publishing Corporation, p. 9, 2011. 1741-427X http://hdl.handle.net/11449/7500 10.1093/ecam/nep123 WOS:000293413300001 WOS000293413300001.pdf |
| Idioma(s) |
eng |
| Publicador |
Hindawi Publishing Corporation |
| Relação |
Evidence-based Complementary and Alternative Medicine |
| Direitos |
openAccess |
| Tipo |
info:eu-repo/semantics/article |
