Ruthenium (II) phosphine/picolinate complexes as antimycobacterial agents
Contribuinte(s) |
Universidade Estadual Paulista (UNESP) |
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Data(s) |
20/05/2014
20/05/2014
01/02/2010
|
Resumo |
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Processo FAPESP: 08/10390-2 Processo FAPESP: 09/06499-1 The synthesis, characterization and the anti-Mycobacterium tuberculosis (MTB) activities of three ruthenium complexes containing the 2-pyridinecarboxylic acid anion (picolinate), with formulae cis-[Ru(pic)(dppm)(2)]PF(6) (1), Cis- [Ru(pic)(dppe)(2)]PF(6) (2) and [Ru(pic)(2)(PPh(3))(2)] (3) [pic = 2-pyridinecarboxylate; dppm = bis(diphenylphosphino)methane: dppe = 1,2-bis(diphenylphosphino)ethane; PPh(3) = triphenylphosphine] are reported in this article. The complexes were characterized by elemental analysis, spectroscopic and electrochemical techniques. Their in vitro anti mycobacterial activity was determinated as the Minimum Inhibitory Concentration (MIC) for MTB cell growth, measured by the REMA method. The best MICs were found for complexes (1) and (2), with values of 0.78 and 0.26 mu g/mL, respectively. The results are comparable to or better than "first line" or "second line" drugs commonly used in the treatment of TB. (C) 2009 Elsevier Masson SAS. All rights reserved. |
Formato |
598-601 |
Identificador |
http://dx.doi.org/10.1016/j.ejmech.2009.10.049 European Journal of Medicinal Chemistry. Paris: Elsevier France-editions Scientifiques Medicales Elsevier, v. 45, n. 2, p. 598-601, 2010. 0223-5234 http://hdl.handle.net/11449/7480 10.1016/j.ejmech.2009.10.049 WOS:000274773300022 |
Idioma(s) |
eng |
Publicador |
Elsevier France-editions Scientifiques Medicales Elsevier |
Relação |
European Journal of Medicinal Chemistry |
Direitos |
closedAccess |
Palavras-Chave | #Antimycobacterial agents #Mycobacterium tuberculosis #REMA #Ruthenium (II) Complexes #Phosphines #Picolinate |
Tipo |
info:eu-repo/semantics/other |