5-HT1A receptors in the dorsal hippocampus mediate the anxiogenic effect induced by the stimulation of 5-HT neurons in the median raphe nucleus
Contribuinte(s) |
Universidade Estadual Paulista (UNESP) |
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Data(s) |
20/05/2014
20/05/2014
01/04/2008
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Resumo |
We evaluated the involvement of dorsal hippocampus (DH) 5-HT1A receptors in the mediation of the behavioral effects caused by the pharmacological manipulation of 5-HT neurons in the median raphe nucleus (MRN). To this end, we used the rat elevated T-maze test of anxiety. The results showed that intra-DH injection of the 5-HT1A/7 agonist 8-OH-DPAT facilitated inhibitory avoidance, an anxiogenic effect, without affecting escape. Microinjection of the 5-HT1A antagonist WAY-100635 was ineffective. In the elevated T-maze, inhibitory avoidance and escape have been related to generalized anxiety and panic disorders, respectively. Intra-MRN administration of the excitatory aminoacid kainic acid, which non-selectively stimulates 5-HT neurons in this brain area facilitated inhibitory avoidance and impaired escape performance, but also affected locomotion. Intra-MRN injection of WAY-100635, which has a disinhibitory effect on the activity of 5-HT neurons in this midbrain area, only facilitated inhibitory avoidance. Preadministration of WAY-100635 into the DH blocked the behavioral effect of intra-MRN injection of WAY-100635, but not of kainic acid. These results indicate that DH 5-HT1A receptors mediate the anxiogenic effect induced by the selective stimulation of 5-HT neurons in the MRN. (c) 2007 Elsevier B.V. and ECNP. All rights reserved. |
Formato |
286-294 |
Identificador |
http://dx.doi.org/10.1016/j.euroneuro.2007.07.007 European Neuropsychopharmacology. Amsterdam: Elsevier B.V., v. 18, n. 4, p. 286-294, 2008. 0924-977X http://hdl.handle.net/11449/6485 10.1016/j.euroneuro.2007.07.007 WOS:000254250700007 |
Idioma(s) |
eng |
Publicador |
Elsevier B.V. |
Relação |
European Neuropsychopharmacology |
Direitos |
closedAccess |
Palavras-Chave | #median raphe nucleus #dorsal hippocampus #5-HT1A receptors #serotonin #generalized anxiety and panic |
Tipo |
info:eu-repo/semantics/article |