Thyroid status, but not insulin status, affects expression of avian uncoupling protein mRNA in chicken


Autoria(s): Collin, A.; Taouis, M.; Buyse, J.; Ifuta, N. B.; Darras, V. M.; Van As, P.; Malheiros, R. D.; Moraes, VMB; Decuypere, E.
Contribuinte(s)

Universidade Estadual Paulista (UNESP)

Data(s)

20/05/2014

20/05/2014

01/04/2003

Resumo

The aim of this study was to investigate the hormonal regulation of the avian homolog of mammalian uncoupling protein (avUCP) by studying the impact of thyroid hormones and insulin on avUCP mRNA expression in chickens (Gallus gallus). For 3 wk, chicks received either a standard diet (control group), or a standard diet supplemented with triiodothyronine (T-3; T3 group) or with the thyroid gland inhibitor methimazole (MMI group). A fourth group received injections of the deiodinase inhibitor iopanoic acid (IOP group). During the 4th wk of age, all animals received two daily injections of either human insulin or saline solution. The results indicate a twofold overexpression of avUCP mRNA in gastrocnemius muscle of T3 birds and a clear downregulation (-74%) in MMI chickens compared with control chickens. Insulin injections had no significant effect on avUCP mRNA expression in chickens. This study describes for the first time induction of avUCP mRNA expression by the thermogenic hormone T3 in chickens and supports a possible involvement of avUCP in avian thermogenesis.

Formato

E771-E777

Identificador

http://ajpendo.physiology.org/content/284/4/E771

American Journal of Physiology-endocrinology and Metabolism. Bethesda: Amer Physiological Soc, v. 284, n. 4, p. E771-E777, 2003.

0193-1849

http://hdl.handle.net/11449/4228

10.1152/ajpendo.00478.2002

WOS:000181426100015

Idioma(s)

eng

Publicador

Amer Physiological Soc

Relação

American Journal of Physiology: Endocrinology and Metabolism

Direitos

closedAccess

Palavras-Chave #thyroid hormones #thermogenesis #muscle
Tipo

info:eu-repo/semantics/article