Effects of Low Molecular Weight Sulfated Galactan Fragments From Botryocladia Occidentalis on the Pharmacological and Enzymatic Activity of Spla2 From Crotalus Durissus Cascavella
| Contribuinte(s) |
Universidade Estadual Paulista (UNESP) |
|---|---|
| Data(s) |
20/05/2014
20/05/2014
01/11/2010
|
| Resumo |
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Low molecular weight fragments of sulfated galactans (Boc-5 and Boc-10) from the red algae Botryocladia occidentalis significantly inhibited Crotalus durissus cascavella sPLA2 enzymatic activity. Equimolar ratios of sPLA2 to Boc-5 or Boc-10 resulted in allosteric inhibition of sPLA2. Under the conditions tested, we observed that both Boc-5 and Boc-10 strongly decreased edema, myonecrosis, and neurotoxicity induced by native sPLA2. |
| Formato |
567-571 |
| Identificador |
http://dx.doi.org/10.1007/s10930-010-9294-9 Protein Journal. New York: Springer, v. 29, n. 8, p. 567-571, 2010. 1572-3887 http://hdl.handle.net/11449/336 10.1007/s10930-010-9294-9 WOS:000284644400005 |
| Idioma(s) |
eng |
| Publicador |
Springer |
| Relação |
Protein Journal |
| Direitos |
closedAccess |
| Palavras-Chave | #Botryocladia occidentalis #Crotalus durissus cascavella #Secretory phospholipase A2 (sPLA2) #Edema #Myonecrosis |
| Tipo |
info:eu-repo/semantics/article |
