Caracterização físico-química de complexo de inclusão entre hidroximetilnitrofurazona e hidroxipropil-beta-ciclodextrina
| Contribuinte(s) |
Universidade Estadual Paulista (UNESP) |
|---|---|
| Data(s) |
20/05/2014
20/05/2014
01/01/2008
|
| Resumo |
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Hydroxymethylnitrofurazone (NFOH) is a prodrug that is active against Trypanosoma cruzi. It however presents low solubility and high toxicity. Hydroxypropyl-beta-cyclodextrin (HP-beta-CD) can be used as a drug-delivery system for NFOH modifying its physico-chemical properties. The aim of this work is to characterize the inclusion complex between NFOH and HP-beta-CD. The rate of NFOH release decreases after complexation and thermodynamic parameters from the solubility isotherm studies revealed that a stable complex is formed (deltaGº= 1.7 kJ/mol). This study focuses on the physico-chemical characterization of a drug-delivery formulation that comes out as a potentially new therapeutic option for Chagas disease treatment. |
| Formato |
290-295 |
| Identificador |
http://dx.doi.org/10.1590/S0100-40422008000200019 Química Nova. Sociedade Brasileira de Química, v. 31, n. 2, p. 290-295, 2008. 0100-4042 http://hdl.handle.net/11449/157 10.1590/S0100-40422008000200019 S0100-40422008000200019 WOS:000254295500019 S0100-40422008000200019.pdf |
| Idioma(s) |
por |
| Publicador |
Sociedade Brasileira de Química |
| Relação |
Química Nova |
| Direitos |
openAccess |
| Palavras-Chave | #hydroxymethylnitrofurazone #cyclodextrin #inclusion complex |
| Tipo |
info:eu-repo/semantics/article |
