Ketamine alters oscillatory coupling in the hoppocampus


Autoria(s): Caixeta, Fábio; Cornélio, Alianda; Scheffer-Teixeira, Robson; Ribeiro, Sidarta; Tort, Adriano
Data(s)

02/08/2013

02/08/2013

02/08/2013

Resumo

Recent studies show that higher order oscillatory interactions such as cross-frequency coupling are important for brain functions that are impaired in schizophrenia, including perception, attention and memory. Here we investigated the dynamics of oscillatory coupling in the hippocampus of awake rats upon NMDA receptor blockade by ketamine, a pharmacological model of schizophrenia. Ketamine (25, 50 and 75 mg/kg i.p.) increased gamma and high-frequency oscillations (HFO) in all depths of the CA1-dentate axis, while theta power changes depended on anatomical location and were independent of a transient increase of delta oscillations. Phase coherence of gamma and HFO increased across hippocampal layers. Phase-amplitude coupling between theta and fast oscillations was markedly altered in a dose-dependent manner: ketamine increased hippocampal theta-HFO coupling at all doses, while theta-gamma coupling increased at the lowest dose and was disrupted at the highest dose. Our results demonstrate that ketamine alters network interactions that underlie cognitively relevant theta-gamma coupling.

Identificador

CAIXETA, Fábio et.al. Ketamine alters oscillatory coupling in the hoppocampus. Scientific Reports, v.3, n.2348, ago.2013.

2045-2322

http://repositorio.ufrn.br:8080/jspui/handle/1/6251

Idioma(s)

eng

Publicador

Nature Publishing Group

Direitos

open access

Palavras-Chave #SCHIZOPHRENIA #ESQUIZOFRENIA #EXPERIMENTAL MODELS OF DISEASE #MODELO EXPERIMENTAL DE DOENÇAS #EXTRACELLULAR RECORDING #NEUROPHYSIOLOGY #NEURO FISIOLOGIA
Tipo

article