Efeitos da mal nutrição protéica sobre o metabolismo da glicina em cerebelo de ratos durante o seu desenvolvimento


Autoria(s): Souza, Karine Bresolin de
Contribuinte(s)

Perry, Marcos Luiz Santos

Data(s)

06/06/2007

2003

Resumo

Malnutrition is a worldwide problem affecting millions of unborn and young children during the most vulnerable stages of brain development (1). All restriction of protein during the perinatal period of life can alter the development of mammalian fetus and have marked repercussions on development of the Central Nervous System (CNS). The brain is vulnerable to protein malnutrition with altered morphologic and biochemical maturation, leading to impaired functions. The focus of this study is to investigate [U-14C]glycine metabolism in malnourished rats submitted to pre- and postnatal protein deprivation (diet: 8% protein with addition and without addition of L-methionine) on glycine metabolism of rats (normonourished group: 25% protein). It was observed that protein malnutrition alters oxidation to CO2, conversion to lipids and protein synthesis from [U-14C]glycine in cerebellum of malnourished rats without addition of L-methionine on a diet at 7 and 21 days of postnatal life. Our results also indicate that protein malnutrition causes a retardation in the normally ordered progression of brain development, and the malnourished groups have smaller cells, reduction in cell numbers and smaller cerebellar weight comparing to the control group.

Resumo não disponível.

Formato

application/pdf

Identificador

http://hdl.handle.net/10183/2684

000375156

Idioma(s)

por

Direitos

Open Access

Palavras-Chave #Protein malnutrition #Glicina : Sistema nervoso central : Metabolismo #Proteínas #Glycine metabolism #Cerebellum #Nutrição #Bioquímica
Tipo

Dissertação