Microencapsulation of coupled folate and chitosan nanoparticles for targeted delivery of combination drugs to colon
Data(s) |
01/01/2015
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Resumo |
Folate-chitosan nanoparticles, co-loaded with 5-fluourouacil (5-FU) and leucovorin (LV) and prepared by ionic gelation technology were physically microencapsulated by enteric polymer using a solvent evaporation method. Average particle size of the microencapsulated particles was in the range of 15 to 35 µm. High drug encapsulation efficiency was obtained for both 5-FU and LV in the microencapsulated particles. Both drugs were in amorphous state in the microencapsulated particles. By enteric coating, excellent pH-dependent release profile was achieved and no drug release was observed in simulated gastric and intestinal fluids. However, when the pH value reached the soluble threshold of Eudragit S-100, a constant and slow drug release was observed. The results indicated that these microencapsulated particles are a promising vehicle for selectively targeting drugs to colon in the chemotherapy of colon cancer. |
Identificador | |
Idioma(s) |
eng |
Publicador |
Taylor and Francis |
Relação |
http://dro.deakin.edu.au/eserv/DU:30075880/wang-microencapsulationofcoupled-2015.pdf http://www.dx.doi.org/10.3109/02652048.2014.944947 |
Direitos |
2015, Taylor and Francis |
Palavras-Chave | #5-Fluorourical #colon cancer #drug delivery #leucovorin #microencapsulation #Science & Technology #Physical Sciences #Technology #Life Sciences & Biomedicine #Chemistry, Applied #Engineering, Chemical #Pharmacology & Pharmacy #Chemistry #Engineering #MULTIPARTICULATE SYSTEM #IN-VITRO #GUAR GUM #DESIGN #MICROSPHERES #5-FLUOROURACIL #POLYSACCHARIDES |
Tipo |
Journal Article |