Effects of depression and serotonergic antidepressants on bone: mechanisms and implications for the treatment of depression
Data(s) |
01/01/2016
|
---|---|
Resumo |
Osteoporosis is a chronic skeletal disease marked by microarchitectural deterioration of the bone matrix and depletion of bone mineral density (BMD), with a consequent increased risk for fragility fractures. It has been frequently associated with depression, which is also a chronic and debilitating disorder with high prevalence. Selective serotonin reuptake inhibitors (SSRIs), first-line agents in the pharmacological treatment of mood and anxiety disorders, have also been shown to negatively affect bone metabolism. SSRIs are the most prescribed antidepressants worldwide and a large number of persons at risk of developing osteoporosis, including older patients, will receive these antidepressants. Therefore, a proper musculoskeletal evaluation of individuals who are being targeted for or using SSRIs is a priority. The aim of this article is to review the evidence regarding the effects of depression and serotonergic antidepressants on bone and its implications for clinical care. |
Identificador | |
Idioma(s) |
eng |
Publicador |
Springer |
Relação |
http://dro.deakin.edu.au/eserv/DU:30079518/hodge-effectsofdepression-inpress-2016.pdf http://www.dx.doi.org/10.1007/s40266-015-0323-4 http://www.dx.doi.org/10.1007/s40266-015-0323-4 http://www.ncbi.nlm.nih.gov/pubmed/26547857 |
Direitos |
2016, Springer |
Tipo |
Journal Article |