Synthesis of 2-(Benzylthio)-4-(trifluoromethyl)thiazole-5-carboxylates using S -benzylisothiouronium halides as thiol equivalents
Data(s) |
01/07/2015
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Resumo |
S-Benzylisothiouronium halides are used as shelf-stable, odorless thiol equivalents. The method developed is used to access 2-(benzylthio)-4-(trifluoromethyl)thiazole carboxyl building blocks. Using the latent trifluoromethyl substituent the reactions could be monitored using <sup>19</sup>F NMR spectroscopy. |
Identificador | |
Idioma(s) |
eng |
Publicador |
Georg Thieme |
Relação |
http://dro.deakin.edu.au/eserv/DU:30075595/hickey-synthesisof2-2015.pdf http://www.dx.doi.org/10.1055/s-0034-1380748 |
Direitos |
2015, Georg Thieme |
Palavras-Chave | #19F NMR spectroscopy #isothiouronium halide #nucleophilic aromatic substitution #thiazole #thioether #Science & Technology #Physical Sciences #Chemistry, Organic #Chemistry #F-19 NMR spectroscopy #ONE-POT SYNTHESIS #FUNCTIONALIZED MESOPOROUS SBA-15 #IN-SITU GENERATION #ALKYLISOTHIOURONIUM SALTS #BIOLOGICAL-ACTIVITY #MICHAEL ADDITION #ORGANIC HALIDES #ARYL HALIDES #ODORLESS #THIOETHERS |
Tipo |
Journal Article |