On the use of 'shortcuts' in the method of continuous variation (Job's method)

The use of modified Job plot methodology provides a quick and easy means for evaluating host-guest stoichiometry and requires less material than the original method. In this short paper, the results of a recent anion recognition study using thiourea-functionalised norbornanes and [n]polynorbornanes are presented. A significant difference between the plots constructed using the original and modified method was observed and, as such, caution is advised when the modified Job's method is solely used for the determination of host-guest stoichiometry.