Novel endoperoxides: synthesis and activity against Candida species


Autoria(s): Macreadie, Peter; Avery, Thomas; Greatrex, Ben; Taylor, Dennis; Macreadie, Ian
Data(s)

15/02/2006

Resumo

Fifteen new endoperoxides have been synthesised and tested for activity against pathogenic Candida species. These endoperoxides can be prepared in high yields, in one to three steps, from inexpensive starting materials. Despite chemical and structural similarities, their inhibitory activity against Candida growth varied greatly from one endoperoxide to another, and one species to another. This study of susceptibility to endoperoxide compounds presented here may lead to the development of potent new antifungal agents.

Identificador

http://hdl.handle.net/10536/DRO/DU:30076250

Idioma(s)

eng

Publicador

Elsevier

Relação

http://dro.deakin.edu.au/eserv/DU:30076250/macreadie-novelendoperoxides-2006.pdf

http://www.dx.doi.org/10.1016/j.bmcl.2005.10.101

Direitos

2006, Elsevier

Palavras-Chave #Antifungal #Artemisinin #Endoperoxide
Tipo

Journal Article