Design of endoperoxides with anti-Candida activity


Autoria(s): Avery, Thomas D.; Macreadie, Peter I.; Greatrex, Ben W.; Robinson, Tony V.; Taylor, Dennis K.; Macreadie, Ian G.
Data(s)

01/01/2007

Resumo

Broad antifungal structure-activity relationships governing epoxy-endoperoxides 2 and 3 and their parent endoperoxides 1 are reported. Their inhibitory activity against Candida albicans in conjunction with hemolytic activity and/or growth inhibition of cultured mammalian cells are reported. This information provided guidance for the further development of endoperoxide and epoxy-endoperoxides as topical antifungal agents.

Identificador

http://hdl.handle.net/10536/DRO/DU:30076244

Idioma(s)

eng

Publicador

Elsevier

Relação

http://dro.deakin.edu.au/eserv/DU:30076244/macreadie-designof-2007.pdf

http://www.dx.doi.org/10.1016/j.bmc.2006.10.021

Direitos

2007, Elsevier

Palavras-Chave #Antifungal #Artemisinin #Candida #Endoperoxide #Growth inhibition #Hemolytic activity
Tipo

Journal Article