Design of endoperoxides with anti-Candida activity
| Data(s) |
01/01/2007
|
|---|---|
| Resumo |
Broad antifungal structure-activity relationships governing epoxy-endoperoxides 2 and 3 and their parent endoperoxides 1 are reported. Their inhibitory activity against Candida albicans in conjunction with hemolytic activity and/or growth inhibition of cultured mammalian cells are reported. This information provided guidance for the further development of endoperoxide and epoxy-endoperoxides as topical antifungal agents. |
| Identificador | |
| Idioma(s) |
eng |
| Publicador |
Elsevier |
| Relação |
http://dro.deakin.edu.au/eserv/DU:30076244/macreadie-designof-2007.pdf http://www.dx.doi.org/10.1016/j.bmc.2006.10.021 |
| Direitos |
2007, Elsevier |
| Palavras-Chave | #Antifungal #Artemisinin #Candida #Endoperoxide #Growth inhibition #Hemolytic activity |
| Tipo |
Journal Article |
