Encapsulation of hydrophobic phthalocyanine with poly(N-isopropylacrylamide)/lipid composite microspheres for thermo-responsive release and photodynamic therapy


Autoria(s): Liu,J; Li,J; Zhang,Z; Weng,Y; Chen,G; Yuan,B; Yang,K; Ma,Y
Data(s)

01/04/2014

Resumo

Phthalocyanine (Pc) is a type of promising sensitizer molecules for photodynamic therapy (PDT), but its hydrophobicity substantially prevents its applications. In this study, we efficiently encapsulate Pc into poly(N-isopropylacrylamide) (pNIPAM) microgel particles, without or with lipid decoration (i.e., Pc@pNIPAM or Pc@pNIPAM/lipid), to improve its water solubility and prevent aggregation in aqueous medium. The incorporation of lipid molecules significantly enhances the Pc loading efficiency of pNIPAM. These Pc@pNIPAM and Pc@pNIPAM/lipid composite microspheres show thermo-triggered release of Pc and/or lipid due to the phase transition of pNIPAM. Furthermore, in the in vitro experiments, these composite particles work as drug carriers for the hydrophobic Pc to be internalized into HeLa cells. After internalization, the particles show efficient fluorescent imaging and PDT effect. Our work demonstrates promising candidates in promoting the use of hydrophobic drugs including photosensitizers in tumor therapies. © 2014 by the authors.

Identificador

http://hdl.handle.net/10536/DRO/DU:30070573

Idioma(s)

eng

Publicador

MDPI AG

Relação

http://dro.deakin.edu.au/eserv/DU:30070573/liu-encapsulationofhydr-2014.pdf

http://www.dx.doi.org/10.3390/ma7053481

Direitos

2014, MDPI AG

Palavras-Chave #Composite microsphere #Controlled release #Phospholipid #Photodynamic therapy #Phthalocyanine
Tipo

Journal Article