The STARS signaling pathway: a key regulator of skeletal muscle function
Data(s) |
01/09/2014
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Resumo |
During the last decade, the striated muscle activator of Rho signaling (STARS), a muscle-specific protein, has been proposed to play an increasingly important role in skeletal muscle growth, metabolism, regeneration and stress adaptation. STARS influences actin dynamics and, as a consequence, regulates the myocardin-related transcription factor A/serum response factor (MRTF-A/SRF) transcriptional program, a well-known pathway controlling skeletal muscle development and function. Muscle-specific stress conditions, such as exercise, positively regulates, while disuse and degenerative muscle diseases are associated with a downregulation of STARS and its downstream partners, suggesting a pivotal role for STARS in skeletal muscle health. This review provides a comprehensive overview of the known role and regulation of STARS and the members of its signaling pathway, RhoA, MRTF-A and SRF, in skeletal muscle. |
Identificador | |
Idioma(s) |
eng |
Publicador |
Springer |
Relação |
http://dro.deakin.edu.au/eserv/DU:30067308/lamon-thestarssignaling-2014.pdf http://www.dx.doi.org/10.1007/s00424-014-1475-5 http://www.ncbi.nlm.nih.gov/pubmed/24557714 |
Direitos |
2014, Springer |
Palavras-Chave | #ABRA #MS1 #Skeletal muscle #STARS #Science & Technology #Life Sciences & Biomedicine #Physiology #SERUM-RESPONSE FACTOR #UBIQUITIN-PROTEASOME PATHWAY #FOCAL ADHESION KINASE #RHO-FAMILY GTPASES #ALPHA-ACTIN GENE #MYOGENIC DIFFERENTIATION #SATELLITE CELL #SMOOTH-MUSCLE #FACTOR SRF #TRANSCRIPTIONAL COACTIVATORS |
Tipo |
Journal Article |