MicroRNA profiling in brown adipose tissue and muscle-derived CD34+ cells
Contribuinte(s) |
Russell, Aaron Wadley, Glenn |
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Data(s) |
03/04/2014
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Resumo |
The major findings established a mouse brown adipose tissue (BAT)-enriched miRNA profile conserved in human BAT and predicted to target genes potentially involved in growth and development. The present results also identified a human skeletal muscle-derived CD34+ cell population with the capacity to differentiate into brown adipocytes in vitro. These CD34+ expressed common miRNAs to mouse and human BAT. Finally these findings show an up-regulation of 4 miRNAs in human adult skeletal muscle following cold exposure. These miRNAs were also present in mouse and human BAT as well as in CD34+ brown adipocytes. |
Identificador | |
Idioma(s) |
eng |
Publicador |
Deakin University, Faculty of Health, School of Exercise and Nutrition Sciences |
Relação |
http://dro.deakin.edu.au/eserv/DU:30067323/guller-license-2014.pdf http://dro.deakin.edu.au/eserv/DU:30067323/guller-microrna-2014A.pdf |
Direitos |
The author |
Palavras-Chave | #obesity #lipids #brown adipose tissue |
Tipo |
Thesis |