In depression, bacterial translocation may drive inflammatory responses, oxidative and nitrosative stress (O&NS) and autoimmune responses directed against O&NS- damaged neoepitopes
Data(s) |
01/05/2012
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Resumo |
<b>Objective:</b> Depression is accompanied by activation of immuno-inflammatory and oxidative and nitrosative stress (IO&NS) pathways, and increased IgM/IgA responses to lipopolysaccharide (LPS) of gram-negative commensal bacteria. The latter suggests that bacterial translocation has caused IgM/IgA responses directed against LPS. Bacterial translocation may drive IO&NS responses.<br /><br /><b>Method:</b> To examine the associations between IgM/IgA responses to LPS and IO&NS measurements, including plasma/serum interleukin-1 (IL-1), tumor necrosis factor (TNF)α, neopterin, lysozyme, oxidized LDL (oxLDL) antibodies, peroxides, and IgM (auto)immune responses against malondialdehyde (MDA), azelaic acid, phophatidyl inositol (Pi), NO-tryptophan and NO-tyrosine in depressed patients and controls.<br /><b><br />Results: </b>We found significant positive associations between IgM/IgA responses to LPS and oxLDL antibodies, IgM responses against MDA, azelaic acid, Pi, NO-tryptophan, and NO-tyrosine. The IgA responses to LPS were correlated with lysozyme. There were no significant positive correlations between the IgM/IgA responses to LPS and IL-1 and neopterin.<br /><b><br />Conclusion</b><b>:</b> The findings show that in depression there is an association between increased bacterial translocation and lysozyme production, an antibacterial compound, O&NS processes, and autoimmune responses directed against O&NS generated neoantigenic determinants. It is suggested that bacterial translocation may drive IO&NS pathways in depression and thus play a role in its pathophysiology. |
Identificador | |
Idioma(s) |
eng |
Publicador |
Wiley - Blackwell Publishing |
Relação |
NHMRC 1027315 NHMRC 1026265 http://dro.deakin.edu.au/eserv/DU:30052719/maes-indepression-2012.pdf http://dx.doi.org/10.1111/j.1600-0447.2012.01908.x |
Palavras-Chave | #depression #inflammation #leaky gut #cytokines #LPS #oxidative stress #chronic fatigue |
Tipo |
Journal Article |