Exercise increases skeletal muscle GLUT4 gene expression in patients with type 2 diabetes
Data(s) |
01/08/2012
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Resumo |
The aim of the study was to determine the effect of a single bout of exercise on GLUT4 gene expression in muscle of patients with type 2 diabetes (T2D) and control subjects, matched for age and body mass index. Nine patients with T2D and nine control subjects performed 60 min of cycling exercise at ∼55% peak power (W<sub>max</sub>). Skeletal muscle biopsies were obtained at baseline, immediately post and 3-h post exercise. GLUT4 mRNA expression increased (p < 0.05) to a similar extent immediately post exercise in control (∼60%) and T2D (∼66%) subjects, and remained elevated (p < 0.05) 3-h post exercise with no differences between groups. Similarly, p-AMP-activated protein kinase, p38 mitogen-activated kinase and proliferator-activated receptor gamma co-activator-alpha mRNA expression were increased (p < 0.05) post exercise, and were not different between the groups. In conclusion, a single bout of exercise increased skeletal muscle GLUT4 mRNA expression in patients with T2D to a similar extent as in control subjects.<br /> |
Identificador | |
Idioma(s) |
eng |
Publicador |
Wiley - Blackwell |
Relação |
NHMRC 1030474 http://dro.deakin.edu.au/eserv/DU:30050136/mcgee-exerciseincreases-2012.pdf http://dx.doi.org/10.1111/j.1463-1326.2012.01585.x |
Palavras-Chave | #exercise #glucose metabolism #type 2 diabetes |
Tipo |
Journal Article |