Effect of deep brain stimulation on nucleus accumbens dopamine in a preclinicla model of antidepressant treatment-resistance
Contribuinte(s) |
[Unknown] |
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Data(s) |
01/01/2011
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Resumo |
<b>Background / Purpose:</b> To determine if clinically effective deep brain stimulation (DBS) of neurosurgical targets for treatment-resistant depression regulates transient mesoaccumbens dopamine release in control and antidepressant-resistant animals (rats).<br /><br /><b>Main conclusion:</b> In control rats, DBS stimulation of either the nucleus accumbens or infralimbic cortex significantly attenuated transient mesoaccumbens dopamine efflux, with nucleus accumbens DBS inducing a greater attenuation than infralimbic DBS. High frequency DBS of both targets induced long-term depression of transient accumbens dopamine release, lasting > 2hr post DBS.<br /><br />Conversely, in antidepressant-resistant rats, infralimbic DBS significantly potentiated transient mesoaccumbens dopamine efflux during stimulation, but failed to induce long-lasting changes in neurotransmission. This suggests that a key mechanism of DBS for treatment-resistant depression is the regulation of dysfunctional mesoaccumbens dopamine neurotransmission. |
Identificador | |
Idioma(s) |
eng |
Publicador |
[Society of Biological Psychiatry] |
Relação |
http://dro.deakin.edu.au/eserv/DU:30047684/tye-effectof-evidence-2011.pdf http://dro.deakin.edu.au/eserv/DU:30047684/tye-effectofdeep-2011.pdf |
Direitos |
2011, SOBP |
Tipo |
Conference Paper |