Underlying neurobiology and clinical correlates of mania status after subthalamic nucleus deep brain stimulation in Parkinson's Disease : a review of the literature
Data(s) |
01/01/2012
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Resumo |
Deep brain stimulation (DBS) is a novel and effective surgical intervention for refractory Parkinson's disease (PD). The authors review the current literature to identify the clinical correlates associated with subthalamic nucleus (STN) DBS-induced hypomania/mania in PD patients. Ventromedial electrode placement has been most consistently implicated in the induction of STN DBS-induced mania. There is some evidence of symptom amelioration when electrode placement is switched to a more dorsolateral contact. Additional clinical correlates may include unipolar stimulation, higher voltage (>3 V), male sex, and/or early-onset PD. STN DBS-induced psychiatric adverse events emphasize the need for comprehensive psychiatric presurgical evaluation and follow-up in PD patients. Animal studies and prospective clinical research, combined with advanced neuroimaging techniques, are needed to identify clinical correlates and underlying neurobiological mechanisms of STN DBS-induced mania. Such working models would serve to further our understanding of the neurobiological underpinnings of mania and contribute valuable new insight toward development of future DBS mood-stabilization therapies. |
Identificador | |
Idioma(s) |
eng |
Publicador |
American Psychiatric Publishing |
Relação |
http://dro.deakin.edu.au/eserv/DU:30047679/tye-underlyingneurobiology-2012.pdf http://dx.doi.org/10.1176/appi.neuropsych.10070109 |
Direitos |
2012, American Psychiatric Association |
Palavras-Chave | #high-frequency stimulation #pallidal stimulation #movement-disorders #striatal dopamine #follow-up #psychotic symptoms #secondary mania #basal ganglia #rats #metabolism |
Tipo |
Journal Article |