Anti-angiogenic therapy for high grade glioma

This is the protocol for a review and there is no abstract. The objectives are as follows:<br /><br />To evaluate the efficacy and toxicity of anti-angiogenic therapy, either alone or in combination with chemotherapy and/or radiotherapy in patients with HGG. Comparisons will be as follows:<br /><br />1. Newly diagnosed HGG treated with radiotherapy and chemotherapy in combination with angiogenesis inhibitor versus without angiogenesis inhibitors.<br />2. First relapse therapy with angiogenesis inhibitor versus without angiogenesis inhibitors.<br />3. Second or third line angiogenesis inhibitors versus therapy without angiogenesis inhibitors.