β-Adrenergic blockers reduce the risk of fracture partly by increasing bone mineral density : Geelong Osteoporosis Study
Data(s) |
01/01/2004
|
---|---|
Resumo |
This population-based study documented β-blocker use in 59/569 cases with incident fracture and 112/775 controls. OR for fracture associated with β-blocker use was 0.68 (95%CI, 0.49–0.96). β-Blockers were associated with higher BMD at the total hip (2.5%) and UD forearm (3.6%) after adjusting for age, anthropometry, and thiazide use. β-Blocker use is associated with reduced fracture risk and higher BMD.<br /><b><br />Introduction: </b>Animal data suggests that bone formation is under β-adrenergic control and that β-blockers stimulate bone formation and/or inhibit bone resorption.<br /><br /><b>Materials and Methods: </b>We evaluated the association between β-blocker use, bone mineral density (BMD), and fracture risk in a population-based study in Geelong, a southeastern Australian city with a single teaching hospital and two radiological centers providing complete fracture ascertainment for the region. β-Blocker use was documented for 569 women with radiologically confirmed incident fractures and 775 controls without incident fracture. Medication use and lifestyle factors were documented by questionnaire.<br /><b><br />Results: </b>Odds ratio for fracture associated with β-blocker use was 0.68 (95% CI, 0.49–0.96) for any fracture. Adjusting for age, weight, medications, and lifestyle factors had little effect on the odds ratio. β-Blocker use was associated with a higher BMD at the total hip (2.5%, p = 0.03) and ultradistal forearm (3.6%, p = 0.04) after adjustment for age, anthropometry, and thiazide use.<br /><b><br />Conclusion: </b>β-Blockers are associated with a reduction in fracture risk and higher BMD.<br /> |
Identificador | |
Idioma(s) |
eng |
Publicador |
Wiley - Blackwell |
Relação |
http://dro.deakin.edu.au/eserv/DU:30042803/pasco-badrenergic-2004.pdf http://dx.doi.org/10.1359/jbmr.0301214 |
Direitos |
2004, American Society for Bone and Mineral Research |
Palavras-Chave | #β-blocker #fracture #bone densitometry #population studies #case-control studies |
Tipo |
Journal Article |