Elevated levels of triglyceride and triglyceride-rich lipoprotein triglyceride induced by a high-carbohydrate diet is associated with polymorphisms of AP0A5-1131T>C and AP0C3-482C> in chinese healthy young adults
Data(s) |
01/06/2011
|
---|---|
Resumo |
<b>Background/aims:</b> Changes in lipid profiles have been shown to be associated with diet and apolipoprotein (APO) polymorphisms. Therefore, 2 polymorphisms, i.e. APOA5-1131T>C and APOC3-482C>T, and serum lipids were examined in a Chinese healthy young population with high-carbohydrate/low-fat (HC/LF) diet intervention.<br /><br /><b>Methods:</b> After a wash-out diet for 7 days, 56 young adults (22.89 +/- 1.80 years) received the HC/LF diet for 6 days. Body mass index (BMI) and fasting serum lipid profiles at baseline, after the wash-out diet, and after the HC/LF diet were measured.<br /><br /><b>Results:</b> APOA5-1131C carriers had higher triglyceride (TG) and TG-rich lipoprotein TG (TRL-TG) levels at baseline and after the HC/LF diet, though this mainly corresponded to the female cohort. APOC3-482T carriers had higher TRL-TG levels following the wash-out and HC/LF diets, but these were not directly attributable to a single gender.<br /><br /><b>Conclusions:</b> Both polymorphisms may play an important role in the elevated TG and TRL-TG levels induced by the HC/LF diet, especially in females, thus indicating a potential dietary prevention of coronary heart disease in this Chinese cohort.<br /> |
Identificador | |
Idioma(s) |
eng |
Publicador |
S. Karger AG |
Relação |
http://dro.deakin.edu.au/eserv/DU:30042587/duan-elevatedlevels-2011.pdf http://dro.deakin.edu.au/eserv/DU:30042587/duan-elevatedlevels-evid-2011.pdf http://dx.doi.org/10.1159/000327913 |
Direitos |
2011, S. Karger AG |
Palavras-Chave | #apolipoproteins A5 C3 #high-carbohydrate/low-fat diet #polymorphisms #serum lipids |
Tipo |
Journal Article |