An improved process for the N-demethylation of opiate alkaloids using an iron(II) catalyst in acetate buffer
| Data(s) |
02/01/2009
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|---|---|
| Resumo |
An improved process to N-demethylate opiate alkaloids utilising a solution of the ferrous porphyrin, tetrasodium 5,10,15,20-tetra(4-sulfophenyl)porphyrinatoiron(II) [=Fe(II)-TPPS (8)], in acetate buffer is described. This method provided the corresponding N-demethylated opiates in good yield with high reproducibility.<br /> |
| Identificador | |
| Idioma(s) |
eng |
| Publicador |
Wiley - V C H Verlag GmbH & Co. KGaA |
| Relação |
http://dro.deakin.edu.au/eserv/DU:30039317/ashton-improved-2009.pdf http://dx.doi.org/10.1002/adsc.200800632 |
| Direitos |
2009, Wiley-VCH Verlag GmbH&Co. KGaA, Weinheim |
| Palavras-Chave | #alkaloids #Polonovski reaction #N-demethylation #iron(II) porphyrins #amine N-oxides |
| Tipo |
Journal Article |
