The impact of age at onset of bipolar I disorder on functioning and clinical presentation
Data(s) |
01/08/2009
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Resumo |
<b>Objectives:</b> Recent studies have proposed the existence of three distinct subgroups of bipolar 1 disorder based on age at onset (AAO). The present study aims to investigate potential clinical and functional differences between these subgroups in an Australian sample.<br /><br /><b>Methods:</b> Participants (<i>n</i> = 239) were enrolled in the Bipolar Comprehensive Outcomes Study (BCOS), a 2-year longitudinal, observational, cross-sectional study. Assessment measures included the Young Mania Rating Scale (YMRS), Hamilton Depression Rating Scale (HAMD21), Clinical Global Impressions Scale (CGI-BP), SF-36, SLICE/Life Scale, and the EuroQol (EQ-5D). Participants were also asked about their age at the first major affective episode.<br /><br /><b>Results: </b>Three AAO groups were compared: early (AAO < 20, mean = 15.5 ± 2.72; 44.4% of the participants); intermediate (AAO 20–39, mean = 26.1 ± 4.8; 48.14% of the participants) and late (AAO > 40, mean = 50.6 ± 9.04; 7.4% of the participants). Higher rates of depression, suicidal ideation and binge drinking were reported by the early AAO group. This group also reported poorer quality of life in a number of areas. The early AAO group had a predominant depressive initial polarity and the intermediate group had a manic predominance.<br /><br /><b>Conclusion:</b> Early AAO is associated with an adverse outcome.<br /> |
Identificador | |
Idioma(s) |
eng |
Publicador |
Wiley Blackwell |
Relação |
http://dro.deakin.edu.au/eserv/DU:30035565/dodd-impactofageatonset-2009.pdf http://dx.doi.org/10.1111/j.1601-5215.2009.00399.x |
Direitos |
2009, John Wiley & Sons |
Palavras-Chave | #bipolar disorder #depression #mania #psychosis |
Tipo |
Journal Article |