Diagnosis of {alpha}+-thalassemias by determining the ratio of the two {alpha}-globin gene copies by oligonucleotide hybridization and melting curve analysis
Data(s) |
01/09/2005
|
---|---|
Resumo |
Most cases of {alpha}-thalassemia result from large deletions at the {alpha}-globin locus (1). The {alpha}-globin gene cluster contains a tandem array of 2 nearly identical {alpha}-globin genes (HBA; Fig. 1A ) (2). The {alpha}0-thalassemias are characterized by deletions that inactivate both {alpha}-globin genes of a given chromosome, whereas in {alpha}+-thalassemias, one gene remains functional. The most widespread {alpha}+-thalassemias are those designated –{alpha}3.7 and –{alpha}4.2, according to the lengths of the deleted fragments (3).<br /> |
Identificador | |
Idioma(s) |
eng |
Publicador |
American Association for Clinical Chemistry, Inc. |
Relação |
http://dx.doi.org/10.1373/clinchem.2005.051375 |
Tipo |
Journal Article |