The omega-3 fatty acid, DHA, decreases neuronal cell death in association with altered zinc transport
Data(s) |
01/02/2010
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Resumo |
Docosahexaenoic acid (DHA) is the major polyunsaturated fatty acid in neuronal cell membranes. We hypothesize that DHA induces a decrease in neuronal cell death through reduced ZnT3 expression and zinc uptake. Exposure of M17 cells to DHA-deficient medium increased the levels of active caspase-3, relative to levels in DHA-replete cells, confirming the adverse effects of DHA deficiency in promoting neuronal cell death. In DHA-treated M17 cells, zinc uptake was 65% less and ZnT3 mRNA and protein levels were reduced in comparison with DHA-depleted cells. We propose that the neuroprotective function of DHA is exerted through a reduction in cellular zinc levels that in turn inhibits apoptosis.<br /> |
Identificador | |
Idioma(s) |
eng |
Publicador |
Elsevier |
Relação |
http://dro.deakin.edu.au/eserv/DU:30023634/sinclair-omega3fattyacid-2010.pdf http://dx.doi.org/10.1016/j.febslet.2009.12.013 |
Direitos |
2009, Elsevier |
Palavras-Chave | #DHA #omega-3 fatty acid #zinc #ZnT3 #M17 human neuronal cell #apoptosis |
Tipo |
Journal Article |