Is grand multiparity associated with an increased risk of dysglycaemia?
Data(s) |
01/07/2006
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Resumo |
Aims/hypothesis: We sought to determine the risk of diabetes and IGT/IFG with grand multiparity. Subjects, materials and methods: Women, aged ≥25 years, from the Australian Diabetes, Obesity and Lifestyle Study and the Crossroads Undiagnosed Disease Study (a rural study in Victoria, Australia), participated in a household census (response 67 and 70%, respectively), subsequently attending a biomedical examination that included an oral glucose tolerance test (58% [6198] and 69% [819]). Results: After adjusting for age, obesity and socio-economic status, diabetes, but not IGT/IFG, was less common among women with a parity of 1 to 2 (odds ratio [OR]=0.64 [0.48– 0.84]) and 3 to 4 (OR=0.72 [0.53–0.96]) than in grand multiparous women. This relationship was unrelated to past hysterectomy, use of the oral contraceptive pill or menopausal status. Conclusions/interpretation: Grand multiparity is associated with an increased risk of diabetes but not of IGT/IFG.We postulate that parity accelerates transition from IGT/IFG to diabetes, more than it does transition from normal glucose tolerance to IGT/IFG.<br /> |
Identificador | |
Idioma(s) |
eng |
Publicador |
Springer-Verlag |
Relação |
http://dro.deakin.edu.au/eserv/DU:30021379/cameron-isgrand-2006.pdf http://dx.doi.org/10.1007/s00125-006-0276-6 |
Direitos |
2006, Springer-Verlag |
Palavras-Chave | #diabetes #hysterectomy #menopause #oral contraceptive pill #parity |
Tipo |
Journal Article |