The significance of transfusion in the past as a risk for current hepatitis B and Hepatitis C infection: a study in endoscopy patients
Data(s) |
01/04/2005
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Resumo |
<b>BACKGROUND:</b> The objective was to determine the contribution of transfusion in the past to the risk of current infection with hepatitis B or C among patients attending a large hospital for endoscopic procedures.<br /><b>STUDY DESIGN AND METHODS</b>: Blood samples had been tested for hepatitis markers by routine methods. Patients completed a comprehensive risk factor questionnaire and results were analyzed using computer software.<br /><b>RESULTS</b>: Twenty-seven percent of the 2120 participants in the study received transfusions in the past. There was no increase in prevalence of hepatitis B among those transfused. Compared with nontransfused participants, recipients of blood before the implementation of hepatitis C virus (HCV) screening in 1990 had a 4.6-fold increased risk of HCV infection, whereas those transfused with screened blood had a 3-fold increased risk. The difference between the odds ratios for patients before and after screening was not significant.<br /><b>CONCLUSIONS:</b> Because screening has almost completely eliminated HCV from the blood supply, our finding of a continuing association of HCV infection with transfusion was unexpected. It implies that there are significant other nosocomial risks for hepatitis C transmission associated with the clinical situations where patients received blood. These should be actively investigated.<br /> |
Identificador | |
Idioma(s) |
eng |
Publicador |
Blackwell Publishing, Inc. |
Relação |
http://dro.deakin.edu.au/eserv/DU:30009362/n20070272.pdf http://dx.doi.org/10.1111/j.1537-2995.2005.04317.x |
Direitos |
1999-2008 John Wiley & Sons, Inc. |
Tipo |
Journal Article |