Effect of dietary omega-3 fatty acid deficiency on heart rate variability in hooded rats
Data(s) |
01/01/2007
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Resumo |
<b>Introduction</b>: Recent reports in adult humans suggest that heart rate variability is modulated by the concentration of omega-3 polyunsaturated fatty acids (PUFA) contained in blood cell membranes. <b>Material and methods</b>: Hurst analysis of ECG data was conducted on 12 male adult hooded (Long-Evans) rats, representing the 3rd generation to be fed diets that were either deficient in, or supplemented with, omega-3 PUFA. ECG data were obtained from surface electrodes and 4000 beats were analyzed for each animal. <b>Results</b>: Dietary manipulation, despite leading to large changes in tissue omega- 3 PUFA levels, did not significantly affect the complexity of heart rate dynamics, with Hurst exponent (H) values of 0.15±0.02 and 0.12±0.03, for animals fed omega- 3 fatty acid-adequate and -deficient diets, respectively. Mean heart rate was also unaffected by the diets. A power calculation revealed that about one hundred animals per group would have been required to avoid a type II error. <b>Conclusions</b>: According to this model of dietary PUFA manipulation, omega-3 fatty acids are unlikely to exert a large effect on the autonomic functions that control heart rate variability. Prospective studies into the effect of omega-3 fatty acids on HRV should consider the need for large sample size as estimated by the results contained in this report.<br /> |
Identificador | |
Idioma(s) |
eng |
Publicador |
Termedia Wydawnictwo |
Relação |
http://dro.deakin.edu.au/eserv/DU:30007688/sinclair-effectof-2007.pdf http://www.termedia.pl/showpdf.php?article_id=9003 |
Direitos |
2007, Termedia Wydawnictwo |
Palavras-Chave | #omega-3 fatty acids #heart rate variability (HRV) #Hurst exponent |
Tipo |
Journal Article |