Genetic studies of body mass index yield new insights for obesity biology


Autoria(s): Locke, Adam E; Kahali, Bratati; Berndt, Sonja I; Justice, Anne E; Pers, Tune H; Day, Felix R; Powell, Corey; Vedantam, Sailaja; Ärnlöv, Johan; Speliotes, Elizabeth K
Data(s)

2015

Resumo

Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in upto 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 x 10(-8)), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for similar to 2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous systemin obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.

Formato

application/pdf

Identificador

http://urn.kb.se/resolve?urn=urn:nbn:se:du-21320

doi:10.1038/nature14177

PMID 25673413

ISI:000349190300031

Idioma(s)

eng

Publicador

Högskolan Dalarna, Medicinsk vetenskap

Relação

Nature, 0028-0836, 2015, 515:7538, s. 197-206

Direitos

info:eu-repo/semantics/openAccess

Tipo

Article in journal

info:eu-repo/semantics/article

text

Palavras-Chave #Clinical Medicine #Klinisk medicin