Analytical Potentialities of Carbon Nanotube/Silicone Rubber Composite Electrodes: Determination of Propranolol

A new composite electrode based on multiwall carbon nanotubes (MWCNT) and silicone-rubber (SR) was developed and applied to the determination of propranolol in pharmaceutical formulations. The effect of using MWCNT/graphite mixtures in different proportions was also investigated. Cyclic voltammetry and electrochemical impedance spectroscopy were used for electrochemical characterization of different electrode compositions. Propranolol was determined using MWCNT/SR 70% (m/m) electrodes with linear dynamic ranges up to 7.0 mu molL(-1) by differential pulse and up to 5.4 mu molL(-1) by square wave voltammetry, with LODs of 0.12 and 0.078 mu molL(-1), respectively. Analysis of commercial samples agreed with that obtained by the official spectrophotometric method. The electrode is mechanically robust and presented reproducible results and a long useful life.

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Fundação para a Ciência e a Tecnologia de Portugal (FCT)

CAPES/FCT[177/07]

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

FAPESP-Brazil[08/03537-7]

CEMUC

CEMUC[285]

Fundação para a Ciência e a Tecnologia de Portugal (FCT)

FCT, Portugal