Estrogen receptor: Structural differences and potential implications on selectivity examined by the GRID/CPCA approach
| Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
|---|---|
| Data(s) |
20/10/2012
20/10/2012
2008
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| Resumo |
Selective Estrogen Receptor Modulators ( SERMs) have been developed, but the selectivity towards the subtypes ( ER or ER is not well understood. Based on three-dimensional structural properties of ligand binding domains, a model that takes into account this aspect was developed via molecular interaction fields and consensus principal component analysis (GRID/CPCA). |
| Identificador |
LETTERS IN DRUG DESIGN & DISCOVERY, v.5, n.3, p.182-192, 2008 1570-1808 http://producao.usp.br/handle/BDPI/31762 10.2174/157018008784083947 |
| Idioma(s) |
eng |
| Publicador |
BENTHAM SCIENCE PUBL LTD |
| Relação |
Letters in Drug Design & Discovery |
| Direitos |
closedAccess Copyright BENTHAM SCIENCE PUBL LTD |
| Palavras-Chave | #ER subtypes #consensus PCA #selective estrogen receptor modulators #SERM #ligand binding domain #key interactions #LIGAND-BINDING DOMAIN #BREAST-CANCER #BIOLOGICAL EVALUATION #ANALYTICAL SHAPE #QSAR ANALYSIS #DRUG DESIGN #ALPHA #BETA #SITE #ANTIESTROGENS #Chemistry, Medicinal |
| Tipo |
article original article publishedVersion |
