Pyrodysinoic Acid Derivatives from the Marine Sponge Dysidea robusta

Three new nitrogen-containing terpenes related to pyrodysinoic acid (1) have been isolated from the sponge Dysidea robusta collected in Brazil. Isopyrodysinoic acid (2), 13-hydroxyisopyrodysinoic acid (3), and pyrodysinoic acid B (4) were obtained from the crude extract of D. robusta and identified by analysis of spectroscopic data. Pyrodysinoic acid B (4) is the first furodysin or furodysinin sesquiterpene derivative with a trans junction between the two six-membered rings of the 1,2,3,4,4a,7,8,8a-octahydro-1,1,6-trimethylnaphthalene moiety.

American Society of Pharmacognosy

American Society of Pharmacognosy

FAPESP/BlOprospecTA[05/60175-2]

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

NSERC

NSERC

CNPq

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)