An Improved Procedure for the Preparation of [Bis(2,2,2-trifluoroethyl)phosphono]acetic Acid
| Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
|---|---|
| Data(s) |
20/10/2012
20/10/2012
2010
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| Resumo |
A different and improved procedure for the preparation of [bis(2,2,2-trifluoroethyl)phosphono]acetic acid in just one step from bis(2,2,2-trifluoroethyl)phosphonate is described. The protocol employs a Michaelis-Becker reaction between commercially available bis(2,2,2-trifluoroethyl) phosphonate and bromoacetic acid, furnishing [bis(2,2,2-trifluoroethyl)phosphono]acetic acid in 50-54% yield. FAPESP (Research Supporting Foundation of the State of Sao Paulo) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) CNPq |
| Identificador |
SYNTHESIS-STUTTGART, n.2, p.361-363, 2010 0039-7881 http://producao.usp.br/handle/BDPI/31702 10.1055/s-0029-1217086 |
| Idioma(s) |
eng |
| Publicador |
GEORG THIEME VERLAG KG |
| Relação |
Synthesis-stuttgart |
| Direitos |
restrictedAccess Copyright GEORG THIEME VERLAG KG |
| Palavras-Chave | #[bis(2,2,2-trifluoroethyl)phosphono]acetic acid #Horner-Wadsworth-Emmons (HWE) reaction #Michaelis-Becker reaction #Still-Gennari reagents #WADSWORTH-EMMONS REACTION #LEUCASCANDROLIDE-A #PHORBOXAZOLE #OLEFINATION #CARBANIONS #ESTERS #ANALOG #Chemistry, Organic |
| Tipo |
article original article publishedVersion |
