Kinetic resolution of iodophenylethanols by Candida antarctica lipase and their application for the synthesis of chiral biphenyl compounds
| Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
|---|---|
| Data(s) |
20/10/2012
20/10/2012
2010
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| Resumo |
The kinetic resolution of (+/-)-iodophenylethanols was carried out using lipase from Candida antarctica and in some cases the enantiomeric excesses were high (up to >98%). Enantiomerically enriched (S)-iodophenylethanols produced by the enzymatic resolution process were used in the synthesis of chiral biphenyl compounds by the Suzuki reaction with good yields (63-65%). (C) 2010 Elsevier Ltd. All rights reserved. CNPq Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) FAPESP CAPES Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Novo Nordisk (Curitiba-Parana, Brazil) Novo Nordisk (Curitiba-Parana, Brazil) |
| Identificador |
TETRAHEDRON-ASYMMETRY, v.21, n.8, p.926-929, 2010 0957-4166 http://producao.usp.br/handle/BDPI/31678 10.1016/j.tetasy.2010.05.008 |
| Idioma(s) |
eng |
| Publicador |
PERGAMON-ELSEVIER SCIENCE LTD |
| Relação |
Tetrahedron-asymmetry |
| Direitos |
restrictedAccess Copyright PERGAMON-ELSEVIER SCIENCE LTD |
| Palavras-Chave | #BIOCATALYTIC KETONE REDUCTION #SECONDARY ALCOHOLS #ENANTIOSELECTIVE REDUCTION #ENZYMATIC RESOLUTION #PHARMACEUTICAL-INDUSTRY #ASYMMETRIC REDUCTION #POWERFUL TOOL #BIOREDUCTION #DRUGS #ACETOPHENONES #Chemistry, Inorganic & Nuclear #Chemistry, Organic #Chemistry, Physical |
| Tipo |
article original article publishedVersion |
