Use of Experimental Design for the Optimization of the Production of New Secondary Metabolites by Two Penicillium Species
| Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
|---|---|
| Data(s) |
20/10/2012
20/10/2012
2010
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| Resumo |
A fractional factorial design approach has been used to enhance secondary metabolite production by two Penicillium strains. The method was initially used to improve the production of bioactive extracts as a whole and subsequently to optimize the production of particular bioactive metabolites. Enhancements of over 500% in secondary metabolite production were observed for both P. oxalicum and P. citrinum. Two new alkaloids, citrinalins A (5) and B (6), were isolated and identified from P. citrinum cultures optimized for production of minor metabolites. Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) FAPESP as BIOTA/BIOprospecTA[05/60175-2] Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) FAPESP as BIOTA/BIOprospecTA[06/61693-0] |
| Identificador |
JOURNAL OF NATURAL PRODUCTS, v.73, n.11, p.1821-1832, 2010 0163-3864 http://producao.usp.br/handle/BDPI/31663 10.1021/np100470h |
| Idioma(s) |
eng |
| Publicador |
AMER CHEMICAL SOC |
| Relação |
Journal of Natural Products |
| Direitos |
restrictedAccess Copyright AMER CHEMICAL SOC |
| Palavras-Chave | #SOLID-STATE FERMENTATION #RESPONSE-SURFACE METHODOLOGY #ANTI-JUVENILE-HORMONE #CULTURE-CONDITIONS #SUBMERGED FERMENTATION #XYLANASE PRODUCTION #FUNGAL METABOLITES #MYCELIAL GROWTH #OXALICUM ZH-30 #ASPERGILLUS SP #Plant Sciences #Chemistry, Medicinal #Pharmacology & Pharmacy |
| Tipo |
article original article publishedVersion |
