ACE inhibition by astilbin isolated from Erythroxylum gonocladum (Mart.) OE Schulz


Autoria(s): LUCAS-FILHO, M. D.; SILVA, G. C.; CORTES, S. F.; MARES-GUIA, T. R.; FERRAZ, V. Perpetua; SERRA, C. P.; BRAGA, F. C.
Contribuinte(s)

UNIVERSIDADE DE SÃO PAULO

Data(s)

20/10/2012

20/10/2012

2010

Resumo

Erythroxylum species have several traditional uses in different countries, including the treatment of hypertension. The ethanol extract from E. gonocladum aerial parts, a species endemic to the Brazilian cerrado, elicited a concentration-dependent inhibition of angiotensin converting enzyme (ACE) (pIC(50)=4.53 +/- 0.05). Extract fractionation led to the isolation of two compounds, whose structures were assigned by spectrometric data as astilbin and beta-sitosterol, along with a mixture of palmitic, stearic and linolenic acids. This is the first report on the occurrence of these compounds on E. gonocladum. Astilbin promoted significant ACE inhibition in vitro (pIC(50)=5.86 +/- 0.33) and its activity did not differ from captopril, when both compounds were assayed at 10 mu M concentration. (C) 2009 Elsevier GmbH. All rights reserved.

CNPq - Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (Brazil)

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

CAPES (Brazil)

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

CNPq (Brazil)

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Identificador

PHYTOMEDICINE, v.17, n.5, p.383-387, 2010

0944-7113

http://producao.usp.br/handle/BDPI/31485

10.1016/j.phymed.2009.09.008

http://dx.doi.org/10.1016/j.phymed.2009.09.008

Idioma(s)

eng

Publicador

ELSEVIER GMBH, URBAN & FISCHER VERLAG

Relação

Phytomedicine

Direitos

restrictedAccess

Copyright ELSEVIER GMBH, URBAN & FISCHER VERLAG

Palavras-Chave #In vitro ACE inhibitory activity #Astilbin #Erythroxylum gonocladum #CONVERTING ENZYME ACE #FLAVONOIDS #CHEMOTAXONOMY #ALKALOIDS #PLANTS #Plant Sciences #Chemistry, Medicinal #Pharmacology & Pharmacy
Tipo

article

original article

publishedVersion