Alkaloids from the Bark of Guatteria hispida and Their Evaluation as Antioxidant and Antimicrobial Agents

Phytochemical investigation of the bark of Guatteria hispida afforded three new alkaloids, 9-methoxy-O-methylmoschatoline (1), 9-methoxyisomoschatoline (2), and isocerasonine (3), along with 10 known alkaloids, 8-oxopseudopalmatine (4), O-methylmoschatoline (5), lysicamine (6), liriodenine (7), 10-methoxyliriodenine (8), nornuciferine (9), anonaine (10), xylopine (11), coreximine (12), and isocoreximine (13). The major compounds, 2, 6, 12, and 13, showed significant antioxidant capacity in the ORAC(FL), assay. Compounds 5, 6, and 7 were active against S. epidermidis and C. dubliniensis, with MIC values in the range 12.5-100 mu g mL(-1).

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

CAPES

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

CNPq

FINEP

Financiadora de Estudos e Projetos (FINEP)

FAPESP

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

INCT-Project Controle Biorracional de Insetos Pragas

INCT-Project ""Controle Biorracional de Insetos Pragas""[573742/2008-1]