Molecular modeling and UV-vis spectroscopic studies on the mechanism of action of reversed chloroquine (RCQ)
| Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
|---|---|
| Data(s) |
20/10/2012
20/10/2012
2011
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| Resumo |
Reversed chloroquine (RCQ) is a multiple ligand compound active against chloroquine-sensitive and resistant falciparum malaria. It is composed by a 4-aminoquinoline moiety (like that present in chloroquine (CQ)) joined to imipramine (IMP), a modulating agent that also showed intrinsic antiplasmodial activity against Brazilian Plasmodium falciparum isolates resistant to CQ. Molecular modeling and ultraviolet-visible spectroscopy (UV-vis) studies strongly suggest that the interaction between RCQ and heme is predominant through the quinoline moiety in a mechanism of action similar to that observed for CQ. (C) 2010 Elsevier Ltd. All rights reserved. CAPES-ProDoc[00019 03-8] Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) CNPq Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) |
| Identificador |
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.21, n.1, p.250-254, 2011 0960-894X http://producao.usp.br/handle/BDPI/31431 10.1016/j.bmcl.2010.11.019 |
| Idioma(s) |
eng |
| Publicador |
PERGAMON-ELSEVIER SCIENCE LTD |
| Relação |
Bioorganic & Medicinal Chemistry Letters |
| Direitos |
restrictedAccess Copyright PERGAMON-ELSEVIER SCIENCE LTD |
| Palavras-Chave | #Reversed chloroquine #Chloroquine #Heme #Antimalarial #Multiple ligand #BETA-HEMATIN FORMATION #PLASMODIUM-FALCIPARUM #FERRIPROTOPORPHYRIN-IX #ANTIMALARIAL #MALARIA #DESIPRAMINE #INHIBITION #RESISTANCE #DISCOVERY #RECEPTOR #Chemistry, Medicinal #Chemistry, Organic |
| Tipo |
article original article publishedVersion |
