Synthesis Optimization of Hydroxymethylnitrofurazone, an Antichagasic Candidate, Using 3(2) Factorial Design
| Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
|---|---|
| Data(s) |
20/10/2012
20/10/2012
2010
|
| Resumo |
Hydroxymethylnitrofurazone presents in vitro activity against Trypanosoma cruzi. The optimization of the synthesis of this compound was performed through a 3(2) factorial statistical design. Quadratic model produced the best response surface predicting a maximum yield (82%) close to the center design point with a seven hours reaction and a 1:1.5 (NF:K(2)CO(3)) ratio. FAPESP[01/01192-3] Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) FAPESP[04/06097-7] Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) CNPq |
| Identificador |
LETTERS IN ORGANIC CHEMISTRY, v.7, n.3, p.191-195, 2010 1570-1786 |
| Idioma(s) |
eng |
| Publicador |
BENTHAM SCIENCE PUBL LTD |
| Relação |
Letters in Organic Chemistry |
| Direitos |
closedAccess Copyright BENTHAM SCIENCE PUBL LTD |
| Palavras-Chave | #Factorial design #synthesis optimization #hydroxymethylnitrofurazone (NFOH) #antichagasic candidate #response surface methodology #TRYPANOSOMA-CRUZI #Chemistry, Organic |
| Tipo |
article original article publishedVersion |
