Chemoenzymatic synthesis of boron-containing chiral amines and amides
| Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
|---|---|
| Data(s) |
20/10/2012
20/10/2012
2010
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| Resumo |
The first application of lipases as catalysts to obtain optically active boron-containing amines and amides is described. We studied several reaction conditions to achieve the kinetic resolution of boron-containing amines via enantioselective acylation mediated by Candida antarctica lipase B (CAL-B). Excellent enantioselectivity (E>200) and high enantiomeric excess (up to >99%) of both the remaining amines and amides were obtained. (C) 2010 Elsevier Ltd. All rights reserved. FAPESP (State of Sao Paulo Research Foundation) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) CNPq (National Counsel of Technological and Scientific Development) |
| Identificador |
TETRAHEDRON-ASYMMETRY, v.21, n.19, p.2419-2424, 2010 0957-4166 http://producao.usp.br/handle/BDPI/31027 10.1016/j.tetasy.2010.09.011 |
| Idioma(s) |
eng |
| Publicador |
PERGAMON-ELSEVIER SCIENCE LTD |
| Relação |
Tetrahedron-asymmetry |
| Direitos |
restrictedAccess Copyright PERGAMON-ELSEVIER SCIENCE LTD |
| Palavras-Chave | #NEUTRON-CAPTURE THERAPY #CROSS-COUPLING REACTION #KINETIC RESOLUTION #ORGANIC-SYNTHESIS #ACID INHIBITORS #LIPASE #ACYLATION #PROTEASOME #CHEMISTRY #CANCER #Chemistry, Inorganic & Nuclear #Chemistry, Organic #Chemistry, Physical |
| Tipo |
article original article publishedVersion |
