TNF-alpha polymorphisms are associated with obsessive-compulsive disorder


Autoria(s): HOUNIE, Ana Gabriela; CAPPI, Carolina; CORDEIRO, Quirino; SAMPAIO, Aline Santos; MORAES, Ivanil; ROSARIO, Maria Conceicao do; PALACIOS, Selma A.; GOLDBERG, Anna Carla; VALLADA, Homero Pinto; MACHADO-LIMA, Ariane; NAKANO, Eduardo; KALIL, Jorge; PAULS, David; PEREIRA, Carlos Alberto B.; GUILHERME, Luiza; MIGUEL, Euripedes Constantino
Contribuinte(s)

UNIVERSIDADE DE SÃO PAULO

Data(s)

20/10/2012

20/10/2012

2008

Resumo

Introduction: Several lines of evidence support an immunologic involvement in obsessive-compulsive disorder (OCD): the increased prevalence of OCD in patients with rheumatic fever (RF), and the aggregation of obsessive-compulsive spectrum disorders among relatives of RF probands. Tumor necrosis factor alpha is a proinflammatory cytokine involved in RF and other autoimmune diseases. Polymorphisms in the promoter region of the TNFA gene have been associated with RE Given the association between OCD and RF, the goal of the present study was to investigate a possible association between polymorphisms within the promoter region of TNFA and OCD. Materials and methods: Two polymorphisms were investigated: -308 G/A and -238 G/A. The allelic and genotypic frequencies of these polymorphisms were examined in 111 patients who fulfilled DSM-IV criteria for OCD and compared with the frequencies in 250 controls. Results: Significant associations were observed between both polymorphisms and OCD. For -238 G/A, an association between the A allele and OCD was observed (X-2 = 12.05, p = 0.0005). A significant association was also observed between the A allele of the -308 G/A polymorphism and OCD (X-2 = 7.09, p = 0.007). Finally, a haplotype consisting of genotypes of these two markers was also examined. Significant association was observed for the A-A haplotype (p = 0.0099 after correcting for multiple testing). Discussion: There is association between the -308 G/A and -238 G/A TNFA polymorphisms and OCD in our Brazilian sample. However, these results need to be replicated in larger samples collected from different populations. (c) 2008 Elsevier Ireland Ltd. All rights reserved.

CAPES/PRODOC, FAPESP[98/15-013-9]

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

CAPES/PRODOC, FAPESP[2005/55628-8]

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

CNPq

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Identificador

NEUROSCIENCE LETTERS, v.442, n.2, p.86-90, 2008

0304-3940

http://producao.usp.br/handle/BDPI/30879

10.1016/j.neulet.2008.07.022

http://dx.doi.org/10.1016/j.neulet.2008.07.022

Idioma(s)

eng

Publicador

ELSEVIER IRELAND LTD

Relação

Neuroscience Letters

Direitos

restrictedAccess

Copyright ELSEVIER IRELAND LTD

Palavras-Chave #case-control study #cytokine #autoimmune #molecular genetics #rheumatic fever #NECROSIS-FACTOR-ALPHA #RHEUMATIC HEART-DISEASE #PROMOTER POLYMORPHISMS #FUNCTIONAL-ANALYSIS #SPECTRUM DISORDERS #GENE POLYMORPHISM #GENOMIC ANCESTRY #MEXICAN PATIENTS #FEVER #SCHIZOPHRENIA #Neurosciences
Tipo

article

original article

publishedVersion