Morphometric analysis of the urethra of castrated female rats treated with tamoxifen
Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
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Data(s) |
20/10/2012
20/10/2012
2008
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Resumo |
Objectives: The aim of this study was to evaluate the effects of tamoxifen on the weight and thickness of the urethral epithelium of castrated female rats. Methods: Forty castrated adult female Wistar-Hannover rats were randomly divided into two groups: Group I (n = 20) in which the animals received only the vehicle (propylene glycol) and Group 11 (n = 20) in which the rats received tamoxifen 250 mu g/day by gavage. After 30 days of treatment, all animals were sacrificed and the urethra was immediately removed for weighing. Next, the urethra was divided into the proximal and distal segments, which were fixed in 10% formaldehyde and submitted to routine histological techniques for morphometric study. The data were analyzed using the weighted minimum mean-square error method and Student`s t-test for two independent samples (p < 0.05). Results: There was a significant increase in the mean weight of the urethra in the rats of Group 11 compared to the control group, 32.0 +/- 2.0 mg and 22.0 +/- 1.6 mg, respectively (p < 0.001). The mean thickness of the distal urethral epithelium of the animals treated with tamoxifen was significantly greater than that of the control group, 42.8 +/- 2.0 mu m and 36.6 +/- 1.5 mu m, respectively (p < 0.001). There was no statistically significant difference between the two groups with respect to the epithelial thickness of the proximal urethra (p = 0.514). Conclusion: Treating castrated adult rats with 250 mu g/day of tamoxifen for 30 days may increase the weight of the urethra and the thickness of the distal urethral epithelium. (c) 2008 Elsevier Ireland Ltd. All rights reserved. |
Identificador |
MATURITAS, v.59, n.3, p.275-280, 2008 0378-5122 http://producao.usp.br/handle/BDPI/30426 10.1016/j.maturitas.2008.02.010 |
Idioma(s) |
eng |
Publicador |
ELSEVIER IRELAND LTD |
Relação |
Maturitas |
Direitos |
restrictedAccess Copyright ELSEVIER IRELAND LTD |
Palavras-Chave | #tamoxifen #rat #urethra #morphometry #epithelium #SERMs #ESTROGEN-RECEPTOR MODULATORS #SURGICAL ADJUVANT BREAST #LOWER URINARY-TRACT #BOWEL PROJECT P-1 #QUALITY-OF-LIFE #CANCER PREVENTION #RALOXIFENE #WOMEN #OSTEOPOROSIS #SYMPTOMS #Geriatrics & Gerontology #Obstetrics & Gynecology |
Tipo |
article original article publishedVersion |