Studies towards the identification of putative bioactive conformation of potent vasodilator arylidene N-acylhydrazone derivatives
| Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
|---|---|
| Data(s) |
20/10/2012
20/10/2012
2009
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| Resumo |
In this report we disclose the synthesis, vasodilatory activity, and identification of bioactive conformation of new N-acylhydrazone and N-methyl-N-acylhydrazone derivatives, structurally designed by bioisosteric replacements of previously described cardioactive compounds LASSBio-294 and its N-methyl derivative LASSBio-785. Some of these novel derivatives presented improved vasorelaxant properties, being new cardiovascular drug candidates. (C) 2009 Elsevier Masson SAS. All rights reserved. CAPES (BR.) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) CNPq (BR.) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) PRONEX (BR.) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ) FAPERJ (BR.) |
| Identificador |
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, v.44, n.10, p.4004-4009, 2009 0223-5234 http://producao.usp.br/handle/BDPI/30180 10.1016/j.ejmech.2009.04.044 |
| Idioma(s) |
eng |
| Publicador |
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER |
| Relação |
European Journal of Medicinal Chemistry |
| Direitos |
restrictedAccess Copyright ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER |
| Palavras-Chave | #N-Acylhydrazone #Vasodilation #Bioactive conformation #DRUG DESIGN #LASSBIO-294 #DISCOVERY #STRATEGY #SAFROLE #AMIDES #AGENTS #Chemistry, Medicinal |
| Tipo |
article original article publishedVersion |
